Notre Dame and USC are considered to be among the most elite programs in college football, with each school winning 11 national championships and 7 Heisman Trophies. This football rivalry, which began in 1926, is considered one of the most important rivalries in college football, and is often called greatest intersectional rivalry in college football, meaning that the rivalry is not dictated by conference affiliation or geography.

Quite often, the winner of this series has gone on to win or play for the college football national title. Both schools combined have produced the most national titles (22), Heisman trophy winners (14) [2], All-Americans, College Football Hall of Famers and future NFL Hall of Famers (21) than any other collegiate series. Also of note is that ND and USC games count for five of the ten most-watched college football games in television history. The teams play for a trophy, called the Jeweled Shillelagh, which goes home with the winner. Notre Dame leads the series 42-32-5, while USC has won the last six contests.

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