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At the core of the melodramatic black comedy are the three Magrath sisters, Meg, Babe and Lenny, who reunite at Old Granddaddy's home in Hazlehurst, Mississippi after Babe shoots her abusive husband. The trio was raised in a dysfunctional family with a penchant for ugly predicaments and each has endured her share of hardship and misery. Past resentments bubble to the surface as they're forced to deal with assorted relatives and past relationships while coping with the latest incident that has disrupted their lives. Each sister is forced to face the consequences of the "crimes of the heart" she has committed.