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Nurse Ratched runs a highly regulated hospital ward with clinical precision. The "acutes" and the "chronics" know the schedule in and out. A charming rogue, McMurphy, who contrives to serve a short sentence in an airy mental institution rather than in prison quickly realizes his mistake. As Nurse Ratched struggles to maintain her control and authority, the inmates' lives are turned upside down and around while she and McMurphy lock horns in battle for their hearts and minds.