Best known for performing with the extended Grateful Dead family, Mark Karan’s soulful blues-based vocal stylings and inspired guitar work hit that sweet spot where rock meets R&B and country, then is blended with the soul of New Orleans and spiked with reggae, folk, funk and whatever else the muse might bring. At “Wednesday Night Live,” Karan will explore new material and approaches with drummer Dave Brogan (ALO); bassist Joe Kyle, Jr. (The Waybacks); Danny Eisenberg on keys (Mother Hips, Ryan Adams); drummer Billy Lee Lewis (Tommy Castro, Roy Rogers, Jemimah Puddleduck); new friends Robert Powell and David Phillips on guitars, pedal steel and dobro; and surprise guests. Doors at 7 p.m., show at 8 p.m.

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